The defending European champions were drawn against the giants – who are chasing a 14th European title – on Friday morning.
However, Chelsea’s tie with the Spanish side could be reversed as both Atletico Madrid and Real Madrid can’t play at home on the same day.
Meanwhile, Premier League giants Manchester City will take on and play Benfica. Additionally, will face Villarreal in the other last-eight tie.
Chelsea booked their place in the last-eight by beating Lille, while Real staged a tremendous comeback to knock out Paris Saint-Germain.
The Blues overcame Real 3-1 on aggregate to reach last season’s final, drawing 1-1 at the Bernabeu before winning 2-0 at Stamford Bridge to progress.
Source: Daily Mail UK