Some communities in Kumasi have been inundated after about 10 hours of rain in the Ashanti Region.
Residents of Apemso and Emina are among the hardest hit by the floods.
Homes have been submerged and commuters stranded in the rush hours of Wednesday.
Some of the victims told JoyNews that the situation has caused them to lose property running into thousands of cedis have also been lost.
Vehicles were also seen covered with rainwater as residents looked on helplessly.
Meanwhile, personnel from the National Disaster Management Authority (NADMO) are assessing the development.
Myjoyonline.com